Zenuwbescherming: neuro-reparatie effecten van PEA via NF-kappa-B

Zenuwbescherming is belangrijk. PEA kan de zenuwen beschermen tegen beschadigingen. Dat worden neuro-protectieve en neuro-reparatoire effecten genoemd. In een letter to the editor werd de rol van PEA besproken in neuroinflammatie en reparatie: ‘Clinical neuro-restaurative effects of palmitoylethanolamide due to Inhibition of inhibition of NF-kappaB?’. De auteur wees erop dat naast PEA ook reparatieve eigenschappen bezit.

Therefore we very much welcome the seminal paper on the relevance of the Inhibition of astroglial NF-kappaB to enhance oligodendrogenesis. This mechanism of action might partly be an explanation for the clinical effects of PEA. And vice versa, the clinical findings related to PEA might be seen as a POC for the thesis of inhibition of astroglial NF-kappa-B inducing an altered inflammatory state that is supportive of oligodendrogenesis after spinal cord injury.

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